Preview and odds analysis for Southampton vs Arsenal at 02:00 on April 5th. Prediction of the result, expected lineup, and expert analysis for the match between Southampton and Arsenal in the FA Cup quarter-finals.
Arsenal travels to St Mary's Stadium having just suffered a setback in the EFL Cup final, where they were convincingly defeated by Manchester City. Their dream of a quadruple has thus been shattered, but Mikel Arteta's squad still has clear opportunities to compete for three other trophies as they lead the Premier League and advance deep in the Champions League. Therefore, the FA Cup remains a crucial target for the Gunners in pursuit of a successful season.
Arsenal's journey to the quarter-finals hasn't been overly difficult, as they successively overcame lower-tier opponents like Portsmouth, Wigan, and Mansfield. However, the 2-1 victory over Mansfield in the previous round showed that the London-based team cannot be complacent, especially when the squad is severely impacted by injuries and a congested fixture schedule. The absence of several key players forced Arteta to use a makeshift lineup, which exposed limitations in the defeat against Man City.

On the other side, Southampton is currently one of the teams with the most impressive form. The Championship representative has been unbeaten in 14 matches across all competitions since the start of the year, including 11 wins. In the FA Cup, they successively defeated Doncaster, Leicester, and notably Fulham to reach the quarter-finals. The victory over Fulham with Ross Stewart's late goal demonstrated the resilient spirit of this team.
Not only performing well in cup competitions, Southampton also maintains stable form in the Championship, securing 10 points from their last 4 matches, thereby gaining a significant advantage in the promotion playoff race. However, having to allocate resources for the promotion goal might prevent them from focusing fully on the FA Cup.
Recent head-to-head history favors Arsenal, as they won all matches against Southampton last season. Nevertheless, playing away with a depleted squad means the Gunners cannot take things lightly.
Still, with superior quality and experience, Arsenal is rated higher. If they perform to their standard, they have the capability to overcome Southampton and secure a spot in the semi-finals, though it likely won't be an easy victory.
Southampton: Downes, Matsuki suspended; Stephens injured; Roerslev long-term absence; Scienza, Welington, Robinson, McCarthy unavailable.
Arsenal: Eze, Madueke, Zubimendi, Rice, Saka, Trossard, Saliba, Gabriel, Timber doubtful; Odegaard injured; Merino definitely unavailable.
Southampton: Peretz; Bree, Wood, Harwood-Bellis, Manning; Jander, Romeu; Fellows, Azaz, Edozie; Stewart
Arsenal: Kepa; White, Salmon, Mosquera, Calafiori; Havertz, Norgaard, Lewis-Skelly; Dowman, Gyokeres, Jesus
21/03/2026: Southampton 2-0 Oxford Utd (Championship)
19/03/2026: Southampton 1-0 Norwich (Championship)
14/03/2026: Coventry 1-2 Southampton (Championship)
12/03/2026: West Brom 1-1 Southampton (Championship)
08/03/2026: Fulham 0-1 Southampton (FA Cup)
22/03/2026: Arsenal 0-2 Manchester City (EFL Cup)
18/03/2026: Arsenal 2-0 Bayer Leverkusen (Champions League)
15/03/2026: Arsenal 2-0 Everton (Premier League)
12/03/2026: Bayer Leverkusen 1-1 Arsenal (Champions League)
07/03/2026: Mansfield 1-2 Arsenal (FA Cup)
25/05/2025: Southampton 1-2 Arsenal (Premier League)
05/10/2024: Arsenal 3-1 Southampton (Premier League)
22/04/2023: Arsenal 3-3 Southampton (Premier League)
23/10/2022: Southampton 1-1 Arsenal (Premier League)
16/04/2022: Southampton 1-0 Arsenal (Premier League)
Arsenal possesses superior quality, but Southampton is in high form and won't be easily subdued at home.